Iraqi Journal of Medical Sciences

Vol. 20 Issue 2 July - December / 2022
Published on website | Date : 2022-11-16 12:56:58

Serum Lipoprotein Ratios as Markers for Insulin Resistance Among Non-Diabetic Acute Coronary Syndrome Patients with Impaired Fasting Glucose

Elaf F. Issa, Manal K. Rasheed


Background: Insulin resistance is a major risk factor in the development of cardiovascular diseases and type 2 diabetes mellitus. Some studies concluded that serum lipoproteins levels and hence lipoprotein ratios were altered in patients with insulin resistance.
Objective: To identify the possibility of using lipoprotein ratios as markers for insulin resistance.
Methods: A cross sectional study conducted in Baghdad (Medical City) and in Maysan (Al Shaheed Al Sadir Teaching Hospital) from February to December 2020. Eighty-three male and 51 female in Coronary Care Unit and Internal Medicine Wards patients were selected in the study group.
Results: Lipoprotein ratios were significantly higher in individuals with homeostatic model assessment for insulin resistance (HOMA-IR) ≥2.5 as compared to subjects with HOMA-IR <2.5. There was a statistically significant association between lipoprotein ratios and insulin resistance when HOMA-IR ≥2.5 (P less than 0.05). Fasting insulin correlated significantly with lipoprotein ratios.
Conclusion: Serum lipoprotein ratios and the best one is triglyceride/high density lipoprotein cholesterol could be used as markers for insulin resistance.
Keywords: Lipoprotein ratios, insulin resistance, diabetes
Citation: Issa EF, Rasheed MK. Serum lipoprotein ratios as markers for insulin resistance among non-diabetic acute coronary syndrome patients with impaired fasting glucose. Iraqi JMS. 2022; 20(2): 239-244. doi: 10.22578/IJMS.20.2.11