Brainstem Auditory Evoked Potential in Patients with Posterior Circulation Ischemic Stroke
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Abstract
Background: Approximately 20% of ischemic strokes affect the posterior circulation of brain structures. Mortality and risk of recurrent stroke are high with the possibility of misdiagnosis. As a result, an effective mode of examination is required for early diagnosis.
Objective: To investigate the clinical diagnostic utility of brainstem auditory evoked potentials (BAEPs) in patients with posterior circulation ischemic stroke (PCIS).
Methods: Twenty patients with PCIS aged 40 to 70 years were studied, along with 20 age-matched healthy controls. Medical history was taken, as well as a clinical neurological examination and BAEPs.
Results: Waves IV and V latencies, and III-V inter-peak latencies were significantly prolonged and wave V amplitude was significantly reduced in patients with PCIS. Fifteen patients with PCIS show retrocochlear (central) dysfunction abnormality. Wave V latency and amplitude showed the highest estimated specificity and sensitivity with 80 % and 90%, respectively. Wave V latency negatively correlated with a duration from onset of stroke to neurophysiological examination.
Conclusion: BAEPs are a useful tool as a biomarker for the clinical evaluation of PCIS. Wave V latency and amplitude is the most specific and sensitive among BAEPs parameter in the diagnosis of PCIS. Topographic distribution of the lost BAEP waves (according to diffusion-weighted MRI findings) may be closely linked to lost generators of individual waves, which suggests regional diagnostic validity of BAEPs. Finally, an early post-stroke BAEPs examination is better in detecting the abnormality and can provide reference values for further evaluation.
Keywords: Posterior circulation ischemic stroke, brainstem auditory evoked potentials
Citation: Tuaimeh MS, Hamdan FB, Al-Hamdani HA. Brainstem auditory evoked potential in patients with posterior circulation ischemic stroke. Iraqi JMS. 2022; 20(2): 191-200. doi: 10.22578/IJMS.20.2.5
Objective: To investigate the clinical diagnostic utility of brainstem auditory evoked potentials (BAEPs) in patients with posterior circulation ischemic stroke (PCIS).
Methods: Twenty patients with PCIS aged 40 to 70 years were studied, along with 20 age-matched healthy controls. Medical history was taken, as well as a clinical neurological examination and BAEPs.
Results: Waves IV and V latencies, and III-V inter-peak latencies were significantly prolonged and wave V amplitude was significantly reduced in patients with PCIS. Fifteen patients with PCIS show retrocochlear (central) dysfunction abnormality. Wave V latency and amplitude showed the highest estimated specificity and sensitivity with 80 % and 90%, respectively. Wave V latency negatively correlated with a duration from onset of stroke to neurophysiological examination.
Conclusion: BAEPs are a useful tool as a biomarker for the clinical evaluation of PCIS. Wave V latency and amplitude is the most specific and sensitive among BAEPs parameter in the diagnosis of PCIS. Topographic distribution of the lost BAEP waves (according to diffusion-weighted MRI findings) may be closely linked to lost generators of individual waves, which suggests regional diagnostic validity of BAEPs. Finally, an early post-stroke BAEPs examination is better in detecting the abnormality and can provide reference values for further evaluation.
Keywords: Posterior circulation ischemic stroke, brainstem auditory evoked potentials
Citation: Tuaimeh MS, Hamdan FB, Al-Hamdani HA. Brainstem auditory evoked potential in patients with posterior circulation ischemic stroke. Iraqi JMS. 2022; 20(2): 191-200. doi: 10.22578/IJMS.20.2.5
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How to Cite
[1]
2022. Brainstem Auditory Evoked Potential in Patients with Posterior Circulation Ischemic Stroke. Iraqi Journal of Medical Sciences. 20, 2 (Oct. 2022).
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How to Cite
[1]
2022. Brainstem Auditory Evoked Potential in Patients with Posterior Circulation Ischemic Stroke. Iraqi Journal of Medical Sciences. 20, 2 (Oct. 2022).