Serum Levels of Interleukin-1 Alpha and Interleukin-6 in Acute Coronary Syndrome Patients

Abstract

Background:Cytokines are responsible for the modulation of immunological and inflammatory processes and play a significant role in the pathogenesis of acute coronary syndrome patients (ACS).
Objective:This study aims to investigate the serum levels of IL-1? and IL-6 in ACS patients.
Methods: The study covered 140 subjects. It comprised a total of 101 patients with ACS patients [62 with acute myocardial infarction (AMI) and 39 with unstable angina (UA)], compared with 39 healthy individuals with no history of cardiac disease. Serum IL-1? and IL-6 analysis was performed by ELISA.
Results:The present results revealed that there were significant elevation in mean serum levels of IL-1? and IL-6 in patients with ACS ( AMI and UA) as compared to healthy control (P<0.001). Moreover, the levels of these cytokines were significantly higher in AMI patients when compared to UA patients (P<0.001).
Conclusion:These finding suggest that IL-1? and IL-6 play an important role in pathogenesis of ACS.
Keywords: Acute coronary syndrome, IL-1? and IL-6.