Impact of Two Different Feeding Regimens for Eight Weeks on Lee Index, Triglyceride Glucose Index and Atherogenic Index of Rats

Abstract

Background:    Obesity, driven by excess calorie and fat intake, contributes to diabetes and cardiovascular disease. In rats, simple indices such as the Lee Index (LI) for obesity, triglyceride‑glucose index (TyGI) for insulin resistance, and atherogenic index of plasma (AIP) for cardiovascular risk provide cost‑effective tools to assess metabolic dysfunction and evaluate dietary or therapeutic interventions.
Objective:    To show the effect of eight weeks of two types of feeding on the LI, TyGI and AIP in rats.
Methods:    A comparative study involved 36 rats, divided into two groups; group 1 received an ordinary lab diet of 20 g per day and group 2 consumed a modified diet of 20 g per day. The studied parameters were the LI, TyGI, and AIP. LI was dependent on weight, and length from nose to anus, TyGI was dependent on triglyceride and glucose, while AIP was dependent on triglyceride and high-density lipoprotein cholesterol. All parameters were measured at 2 intervals (0 and 8) weeks. The study was done at Animal House at the College of Veterinary, University of Baghdad.
Results:    The results showed that the LI did not significantly increase with no differences between the two groups conversely TyGI and AIP increased significantly in the modified and ordinary groups within 8-week intervals.
Conclusion:    Eight weeks of feeding of ordinary and modified diet in rats causes significant rise in TyGI and AIP but not enough to cause a significant change in LI.
Keywords:    Obesity, Lee index, triglyceride glucose index, atherogenic index
Citation:    Oudah AK, Ahmed MH. Impact of two different feeding regimens for eight weeks on Lee index, triglyceride glucose index and atherogenic index of rats. Iraqi JMS. 2025; 23(2): 424-430. doi: 10.22578/IJMS.23.2.25