Vol. 17 Issue 4 July - December / 2019
Published on website | Date : 2020-02-13 11:13:49
7.THE POSSIBLE ROLE OF HCMV IN INFLAMMATORY BOWEL DISEASES IN SAMPLE OF IRAQI PATIENTS
Alaa H. Fadhil, Haider S. Kadhim, Raghad J. Hussain, Sazan A. Al-Atrooshi
Background:Human cytomegalovirus (HCMV) reactivation is one of the most risks that occur in immunosuppressed patients. The association and role of CMV and inflammatory bowel disease (IBD) exacerbation is still controversy.
Objective:To investigate the rate of occurrence and role of HCMV in patients with IBD including demographic and clinical features.
Methods:A cross sectional study involved sixty-five (65) IBD patients whom divided into 9 Crohn’s disease patients and 56 ulcerative colitis patients. The detection of local CMV reactivation (colon) was based on the presence of early and immediately early antigens (nonstructural proteins). The positive results for HCMV reactivation was considered according on Immunohistochemistry (IHC) and/or serological enzyme linked immunosorbent assay (ELISA) results.
Results:Among the 65 eligible IBD patients, nine patients (13.85%) gave positive result for IHC, compared to 56 patients (86.15%) with negative result. On the other hand, only two patients (3.08%) had a positive result for anti-HCMV IgM antibody, while almost all patients (except one) were positive for anti-HCMV IgG antibody. There was a significant difference between positive HCMV and patients with long duration of IBD and non-response to treatment.
Conclusion:IBD and its treatment may put those patients at risk of HCMV reactivation. Colonic active CMV was detected particularly in sever UC patients and significantly in patients with disease duration above 5 years and not response to treatment based on IHC technique for IE and E HCMV proteins detection.
Keywords:Cytomegalovirus, inflammatory bowel disease, ulcerative colitis, Crohn's disease, immunohistochemistry
Citation:Fadhil AH, Kadhim HS, Hussain RJ, Al-Atrooshi SA. The possible role of HCMV in inflammatory bowel diseases in sample of Iraqi patients. Iraqi JMS. 2019; 17(3&4): 207-214. doi: 10.22578/IJMS.17.3&4.7
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