Vol. 15 Issue 4 October - December / 2017
Published on website | Date : 2018-04-09 10:24:55
REMARKABLE ENHANCEMENT OF MEAN PLATELET VOLUME IN IRANIAN PATIENTS WITH TYPE 2 DIABETES MELLITUS WITH NO DEPENDENCE ON HEMOGLOBIN A1C LEVEL
Hojjat Khalili-Hezarjaribi, Shima Mahdavian, Marjaneh Mirsadraei, Roya Farahmand-Bovanlou, Ali Jahanbazi Jahanabad
Background: Diabetes mellitus (DM) is a pandemic disease that leads to several complications. Platelet reactivity plays a major role in diabetes complications. Mean platelet volume (MPV) is a marker of platelet size that is easily determined on routine automated blood counters. Studies have been found that MPV is enhanced in patients with DM.
Objective: To assess any relationship between MPV in type 2 Diabetic persons and with glycohemoglobin (HbA1c) level.
Methods: The study included a total of 130 subjects who were referred to Samenol Aemme and Mehregan hospitals in Mashhad city, Iran, between April 2013 and November 2014 for a routine check-up. All subjects were divided into two groups as following: Patients with type 2 diabetes group, which comprises 63 subjects and non-diabetic control group, which comprises 57 individuals. Blood sample from each individual was collected after a 12-hour overnight fasting. MPV, HbA1c and fasting blood sugar (FBS) were also monitored.
Results: MPV values were found to be 8.7±0.36 fl (p<0.001) and 9.8±0.42 fl (p<0.001) for control and study groups respectively. FBS values were found to be 95.9±10.3 mg/dl (p<0.001) and 202.8±5.1 mg/dl (p<0.001) for control and study groups respectively. MPV values were found to be 9.8±0.28 fl and 9.8±0.46 fl (p=0.813) for diabetic subgroups with HbA1c <7 and HbA1c ≥7 respectively.
Conclusion: The current study showed that׃ i. MPV was enhanced considerably in patients with DM in contrast to healthy controls. ii. Its increase was not dependent on glycemic control reflected by HbA1c.
Keywords: Platelet reactivity, HbA1c measurement, diabetic patients.
Citation: Khalili-Hezarjaribi H, Mahdavian S, Mirsadraei M, Farahmand-Bovanlou R, Jahanabad AJ. Remarkable enhancement of mean platelet volume in iranian patients with type 2 diabetes mellitus with no dependence on hemoglobin A1c level. Iraqi JMS. 2017; Vol. 15(4). 377-382. doi: 10.22578/IJMS.15.4.8.
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