Iraqi Journal of Medical Sciences








Vol. 14 Issue 3 July - September / 2016
Published on website | Date : 2017-01-03 09:22:22

EFFECT OF NIMODIPINE (0.5%) EYE DROPS AGAINST SELENTIE-INDUCED CATARACT IN RABBITS

Dalia A. Shakoor, Adeeb A. Al-Zubaidy, Ban J. Qasim


Abstract

Background:Increase Ca2+‏ level in human lenses found to play a main role in the opacification development.
Objective:To investigate the protective effects of nimodipine (0.5%) eye drops against selenite-induced cataract in rabbits.
Methods: Twenty-four adult rabbits with body weight in a range of (1.5-2 kg) with no signs of ocular inflammation were divided into three groups (apparently normal group, cataract group, nimodipine (0.5%) eye drops group). Cataract induction was done by a single intravitreal injection of sodium selenite solution in right eye. Lens opacity, pupil diameter, intraocular pressure, pupillary response to light, corneal sensation, conjunctival redness, malondialdehyde (MDA) and reduced glutathione (GSH) levels in aqueous humor and histopathological study of lens were evaluated. Apparently, normal group received distilled water.
Results: Nimodipine (0.5%) eye drops resulted in prevention of cataract development, there was no change in pupil diameter, positive pupillary response to light, positive corneal sensation, no conjunctival redness, decreased MDA and increased of GSH levels. Longitudinal lens section showed homogenous appearance and it looked like normal in its feature.
Conclusions: Nimodipine (0.5%) eye drops had prophylactic effect against selenite-induced cataract in rabbits.
Key words: Cataract, nimodipine, selenite.


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