Iraqi Journal of Medical Sciences








Vol. 14 Issue 2 April - June / 2016
Published on website | Date : 2016-09-01 09:44:55

EFFECT OF CHITOSAN AND DEXTRIN COMBINATION ON EXPERIMENTALLY-INDUCED THERMAL INJURY IN RABBITS

Noor A.M. Hassan, Abdulkareem H. Abd, Bahaa F. Hussein


Abstract

Background:Burn is a major health problem, life threatening with a high mortality and morbidity; Chitosan and its formulations are used as a topical dressing in wounds and burns management due to its nontoxic, hemostatic, healing stimulant, antimicrobial, biocompatible and biodegradable properties as well as its vehicle use to deliver biopharmaceuticals, antimicrobials and growth factors into tissue.
Objective:To evaluate the effects of chitosan-dextrin combination on induced burn in rabbits.
Method: Forty domestic male rabbits, weighing 1250-1750 kg were divided into five groups, each of eight animals: AH group: apparently healthy rabbits, BWT group: left with no treatment, AR group: treated with Aqua Rosea, AG-S group: treated with silver sulfadiazine cream and CH-D group: treated with chitosan – dextrin combination; all animals (except AH group) wereinduced burn and treatedtopically on burned area once daily for 28days. Tissue levels ofvascular endothelial cell growth factor (VEGF), tumor necrosis factor alpha (TNF-α) and skin histological examination.
Results: Histopathological evaluation showed enhances inflammatory response, vascularization, granulation tissue formation, and collage deposition due to the appropriate regulation of TNF-α and VEGF.
Conclusion:Topical use of chitosan – dextrin combinationshowed effective and enhance wound healing activities.
Key words:Thermal injury, burn, chitosan, dextrin.


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