Iraqi Journal of Medical Sciences








Vol. 8 Issue 1 January - March / 2010
Published on website | Date : 2016-06-18 15:31:57

POSSIBLE ROLE OF IL-1-Α AND TNF-Α IN BREAST CANCER

Ahmed A .Al-Hassan, Nidhal Abdul Muhymen, Ala'a Ghany Hussien, Leen K. Mustafa , Eman Sh. Al-Obeidy


Abstract

Background: Cytokines have been used as biomarkers in research for prognosis and have been associated with symptoms and adverse outcomes in multiple conditions, including breast cancer.
Objectives: To estimate the concentration of IL-1-α and TNF-α in serum of breast cancer (BC) patients compared with control groups and to detect if there is association of serum levels of these interleukins with disease development.
Subjects and Methods: The levels of IL-1-α and TNF-α were measured by ELISA method in sera of 45 BC patients, 12 patients with benign breast lesions and 23 apparently healthy controls.
Results: Present study was demonstrated that IL-1-α and TNF-α levels were significantly elevated in serum of BC patients as compared with controls (p<0.001), this elevation were significantly associated with poor prognostic factors including advanced stage and estrogen and progesterone receptors-negative status.
Conclusions: Evaluation the serum level of IL--α1and TNF-α may be helpful as predictive non-invasive tests for tumor development in breast cancer patients.
Keywords: Breast cancer, IL--α1, TNF-α.


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