Iraqi Journal of Medical Sciences








Vol. 14 Issue 1 January - March / 2016
Published on website | Date : 2016-05-05 11:13:10

EFFECTS OF METFORMIN ALONE, METFORMIN WITH FLAXSEEDS OIL ON SERUM 1,5 ANHYDROGLUCITOL, ADIPONECTIN AND INSULIN RESISTANCE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

Shatha H. Mohammad, Ahmed R. Abu-Raghif, Nabeel N. Fadhil


Abstract

Background: Adiponectin is an amino acid collagen-like protein that is secreted by adipocytes to acts as a hormone with anti-inflammatory and insulin-sensitizing properties. 1,5 anhydroglucitol, is 1-deoxy form of glucose, is a validated marker of short-term glycemic control. Flaxseed oil is a colorless to yellowish oil obtained from the dried, ripened seeds of the flax plant (Linumusitatissimum, L).
Objectives:To investigate the effects of metformin alone, metformin with flaxseed oil on fasting serum 1,5 anhydroglucitol, adiponectin and insulin resistance.
Methods: Newly diagnosed (≤ 1year) male and female patients with type 2 diabetes mellitus aged 25 to 70 years were enrolled and divided into two groups; group 1 consisted of 32 patients, treated by oral metformim alone over a period of 12 weeks an group 2 consisted of 30 patients treated by oral metformim with flaxseed oil. Fasting serum 1,5 anhydroglucitol, adiponectin, fasting plasma glucose and fasting serum insulin were estimated. All parameters were measured initially, before any intervention, and later on at two steps, the 6th and the 12th week of the study.
Results:After 12 weeks of treatment with metformin alone, metformin with flaxseed oil there was significant improvement in both 1,5 anhydroglucitol (p = 0.010 and 0.013, respectively) and adiponectin (p = 0.041 and 0.037, respectively). For insulin resistance, p value with metformin, metformin with flaxeed oil was 0.105 and 0.110, respectively. Both results showed an apparent improvement only which was statistically insignificant.
Conclusion: Metformin, metformin with flaxseed oil associated with statistically significant improvement in 1,5 anhydroglucitol and adiponectin. Insulin resistance in both treatment groups showed only insignificant apparent improvement. Metformin with flaxseed oil group was more effective in insulin resistance improvement and elevation of adiponectin hormone.
Key words: Adiponectin, 1,5 anhydroglucitol, Homeostasis model assessment for insulin resistance.


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