Iraqi Journal of Medical Sciences

Vol. 9 Issue 3 July - September / 2011
Published on website | Date : 2016-04-11 10:26:04

Pathological Changes in Genital Organs of Female Albino Mice After Treatment with Pentoxifylline

Rajiha A AL-Naimi, Salema L Hassan, Saad S AL-Dujaily


Background:Little to our knowledge has been attempting to show the effect of pentoxifylline (PTX) on ovulation or oogenesis. In a few studies of man with asthenospermia oral treatment with PTX produced significant increase in sperm concentration and motility.
Objective:Study the effect of PTX on ovulation and oogenesis in albino mice.
Methods: Sixty albino mice randomly divided into 6 equal groups: Group 1 received tap water and considered as a control group. Group 2 treated with 16 mg of PTX/Kg/BW/daily for 2 weeks. Group 3, 4, 5, and 6 treated with same dose for 4, 6, 8, 10 weeks respectively. Post-mortem examination done according to the time of treatment and the reproductive systems were excised and processed for light microscopic examination.
Result: PTX administration causes an increase in the diameter of the ovary and in the total number of ovarian follicles and their diameters especially Graafian and secondary follicles. In addition, highly significant increase in the numbers of corpus lutea especially in those groups treated for longer time was noticed. Moreover, an increase in the thickness of uterine and oviduct epithelial lining due to hyperplasia and an increase in the diameter of endometrial glands and oviducts was demonstrated.
Conclusions:We concluded that administration of PTX has a significant effect on the female genital organs especially if given in small doses for 10 weeks. This will definitely influence reproduction and litter size manifested after mating with untreated males.
Key words: Pentoxifylline, ovary, uterus, fallopian tube