Vol. 9 Issue 3 July - September / 2011
Published on website | Date : 2016-04-11 09:48:50
Glutathion, Glutathion Reductase and Gama-glutamyl Transferase Biomarkers for Type 2 Diabetes Mellitus and Coronary Heart Disease
Zainab AA Al-Shamma, Hedef D El-Yassin
Background: Hypercholesterolemia, one of the major risk factors of atherosclerosis, is a major health problem in the world that enhances the free radical generation in various ways. The level of antioxidants was decreased in hypercholesterolemic patients. This depletion of antioxidants may increase in type 2 diabetic patients with hypercholesterolemia, which also may increase the risk of complications from the most common form of diabetes mellitus.
Objective:To evaluate serum reduced glutathione and glutathione reductase as an antioxidant, and gamma-glutamyl transferase as a marker of oxidative stress in both hypercholesterolemic and diabetic-hypercholesterolemic patients.
Methods: The study involved 33 diabetic hypercholesterolemic patients, 37 hypercholesterolemic and 54 healthy control subjects. Ten ml of blood were collected from each patient and normal control subject after an overnight fast for the measurement of gluathion (GSH) glutathione reductase (GR) and gamma-glutamyl transferease (GGT), glucose, lipid profile, urea, creatinine and glycated Hb (HbA1c). The last was for the diabetics only.
Result:Showed a significant decrease in GSH and GR in diabetic-hypercholesterolemic patients compared with hypercholseterolemic patients and a significant increase in GGT in both groups compared with controls. There was a negative correlation between cholesterol with GR in both groups of patients involved in this study and a negative correlation between HbA1c and each of GSH and GR in the diabetic-hypercholesterolemic patients.
Conclusions:High levels of oxidative stress and reduced antioxidants in people with coronary heart disease, previously thought to be markers of the heart condition, could also, indicate a condition of glucose abnormality, such as overt type 2 diabetes.
Key words: hypercholestermia, type 2 diabetes, antioxidants, oxidative stress, GGT.
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