Vol. 11 Issue 1 January - March / 2013
Published on website | Date : 2016-04-03 11:20:22
FINASTERIDE (PLUS ORAL CONTRACEPTIVE PILL) VS METFORMIN IN TREATMENT OF POLYCYSTIC OVARY SYNDROME-RELATED INFERTILITY: A PROSPECTIVE RANDOMIZED TRIAL
Entisar J Al-Mukhtar, Adeeb A Al-Zubaidy, Liqaa M Al-Khuzaee
Background: Polycystic ovary syndrome (PCOS) is a common endocrinopathy characterized by oligo-ovulation or anovulation, signs of androgen excess, and multiple small ovarian cysts. PCOS is thought to be one of the leading causes of female subfertility.
Objective:To evaluate and compare the effects of finasteride vs metformin in treatment of PCOS related infertility.
Methods:Seventy seven infertile married women with an age range between 18 and 35 years were studied complaining from infertility due to PCOS. They were divided into group 1 treated with finasteride (5 mg daily concomitantly with an oral contraceptive pill "OCP" continuously for 2 months) and group 2 was treated continuously for 3 months with metformin (500 mg three times daily).
Results:The percentage of patients responded to metformin treatment was 35.89%, whereas 26.32% of patients were responded to the treatment with finasteride-OCP combination. There were no significant difference between metformin and finasteride in regard to the mean number of mature follicles (1.21±0.43 vs 1.2±0.42) and endometrial thickness (7.26±1.1 vs 7.80±2.25 mm) respectively. The pregnancy rate per patient was higher in metformin treated group in comparison to finasteride treated group (60% vs 21.42%); however, this difference was insignificant (P > 0.05).
Conclusion: Finasteride has a good promising effect in the treatment of infertility due to PCOS, as more patients responded to an oral finasteride-OCP combination in comparison to those responded to an oral metformin monotherapy and the difference in the pregnancy rate of the two groups was not significant.
Keywords: Finasteride, Metformin, Polycystic ovary syndrome, Infertility
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